Parabrachial Nucleus

The nocioceptive-recipient parabrachial nucleus appears to be crucial for the transmission of pain-related information to dopamine neurons. (Coizet 2010). The parabrachial nucleus has 3 major cell divisions - the medial parabrachial nucleus, the lateral prabrachial nucleus, and the kolliker-fuse nucleus (Fulwiler Saper 1984).

Image and Location

Neurosynth structure image:

Neurosynth connectivity image:

Searches

Searches so far:

Most important references

Coizet, V., Dommett, E. J., Klop, E. M., Redgrave, P., & Overton, P. G. (2010). The parabrachial nucleus is a critical link in the transmission of short latency nociceptive information to midbrain dopaminergic neurons. Neuroscience, 168(1), 263-72. Elsevier Inc. doi:10.1016/j.neuroscience.2010.03.049 (Coizet2010.pdf)

Structure

Inputs

-Nociceptive inputs from spinal cord (via lamina I of spinal and medullary dorsal horn) -Ventrolateral NTS, Periambiguous nucleus (Respiratory inputs) -Gustatory inputs (Rostral part of nucleus of solitary tract) -Medial NTS (Visceral) -Area postrema (Chemoceptive)

Outputs

Saper Loewy 1980: pbl_inputs.jpg pbm_inputs.jpg kf_outputs.jpg

Thalamus Hypothalamus Amygdala Bed nucleus of stria terminalis Dorsal raphe nucleus PPTg SNPc, VTA (Note: Most PBN neurons are glutamatergic. Coizet et al suggest that the inhibitory mechanism of PBN may result from PBN outputs onto GABAergic neurons in VTA which could then inhibit DA neurons.)

Functions

Summary list

Nociceptive input Gustatory input Respiratory/locomotor coupling

Nociceptive input to dopamine neurons: short-term inhibition

Effects of stimulation

  • List with references.
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Effects of lesions/inactivation

Effects of microinjection

Coizet 2010:

  • Injections of lidocaine&GABA antagonist muscinol on PBN: No PBN excitation to footshock
  • Lidocaine/muscinol injection also caused reduction/elimination of dopamine inhibitory response to footshock

Optogenetics

  • List with references.
  • Unordered List Item

Other

Gustatory input to DA Neurons

Effects of stimulation

  • List with references.
  • Unordered List Item

Effects of lesions/inactivation

  • Lesions of PBN block increased dopamine overflow in forebrain caused by taste stimuli Hanjal Norjen 2005

Effects of microinjection

  • List with references.
  • Unordered List Item

Optogenetics

  • List with references.
  • Unordered List Item

Other

Studies activating

Coordinates

Coordinates (x, y, z): [0, 0, 0] , [0, 0, 0] Say how overall coordinates were derived here (single study? average? structural landmark?)

Specific study coordinates (if not too many)

Study Description x y z
Fairhurst 2007 Pain Receipt -8 -36 -26 -6 -36 -22
1st Author Name 20xx Contrast Descrip 0 0 0
1st Author Name 20xx Contrast Descrip 0 0 0

List of Studies

Specific, key studies

Saper, C. B., & Loewy, a D. (1980). Efferent connections of the parabrachial nucleus in the rat. Brain research, 197(2), 291-317. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/6478256 Fulwiler, C. E., & Saper, C. B. (1984). Subnuclear Organization of the Efferent Connections Nucleus in the Rat of the Parabrachial, 229-259.

Study list: Coordinate based

Neurosynth results for coordinate(s)

<list studies here from Neurosynth database>

Last modified: 2017/05/13 02:15