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Nucleus Cuneiformis (NCF)

The NCF and PAG are brainstem nuclei involved in a network mediating anti- and pro-nociception, as largely shown from animal data (Fields and Basbaum, 1999 for a review, [Porreca et al., 2002] and [Gebhart, 2004]). Human imaging studies have shown that the PAG and NCF are activated during visceral and somatic pain (Dunckley et al., 2005) and that the NCF plays a key role in the development of experimental secondary hyperalgesia via possible facilitatory pro-nociceptive mechanisms (Zambreanu et al., 2005). The NCF and PAG have been shown to be important in brainstem modulation of pain in humans (Zambreanu et al., 2005), and connections to these nuclei provide an anatomical basis for results of recent studies involving pain control and perception ( [Lorenz et al., 2003], [Valet et al., 2004] and [Wager et al., 2004]). The NCF has recently been shown to be critical for the generation of secondary hyperalgesia in humans (Zambreanu et al., 2005). hadjipavloua2006painbrainstemconnectivitiy_pain.pdf

Image and Location

 NCF and PAG Midbrain anatomy. (Left) A midbrain section adapted with permission from Duvernoy’s Brainstem and Cerebellum atlas (p. 72). (Right) Proton density image showing the equivalent brainstem section and the locations of the NCF and PAG. The cerebral peduncles are highlighted for reference. PAG, periaquaductal grey; NCF, nucleus cuneiformis. hadjipavloua2006painbrainstemconnectivitiy_pain.pdf

The Descending Pain Modulatory SystemNCF (nucleus cuneiformis); PAG (periaqueductal gray); DLPT (dorsolateral pontine tegmentum); ACC (anterior cingulated cortex); +/− indicates both pro- and anti- nociceptive influences, respectively. tracey2007painperception_neuron.pdf

Roles

=Pain Modulation=

Searches

Searches so far: Nucleus Cuneiformis Nucleus Cuneiformis pain Nucleus Cuneiformis emotion Nucleus Cuneiformis pain emotion

Most important references

(classic papers, best papers) APA 5th format from Endnote, e.g.,

Fields, H. L. (2000). Pain modulation: expectation, opioid analgesia and virtual pain.Progress in brain research, 122, 245-253.

Endnote Package Library (with PDFs)

Structure

Inputs Name, and code Strength (L, M, H), Confidence (L, M, H), Transmitter(s)

Outputs Name, and code Strength (L, M, H), Confidence (L, M, H), Transmitter(s)

Functions

Summary list

Function Area 1 [Name]

Effects of stimulation List with references. Unordered List Item

Effects of lesions/inactivation List with references. Unordered List Item

Effects of microinjection List with references. Unordered List Item

Optogenetics List with references. Unordered List Item

Other

Function Area 2 [Name]

Effects of stimulation List with references. Unordered List Item

Effects of lesions/inactivation List with references. Unordered List Item

Effects of microinjection List with references. Unordered List Item

Optogenetics List with references. Unordered List Item

Other

Studies activating

Coordinates Coordinates (x, y, z): [0, 0, 0] , [0, 0, 0] Say how overall coordinates were derived here (single study? average? structural landmark?)

Specific study coordinates (if not too many)

Study Description x y z 1st Author Name 20xx Contrast Descrip 0 0 0 1st Author Name 20xx Contrast Descrip 0 0 0 1st Author Name 20xx Contrast Descrip 0 0 0

List of Studies

Specific, key studies

Study list: Coordinate based Neurosynth results for coordinate(s)

<list studies here from Neurosynth database>

Last modified: 2017/09/27 22:53