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lPAG

Image and Location

Anatomical illustration from Linnman et al.(2012)

Functional Activation map from Linnman et al.(2012) and Buhle et al.(2012)

Connectivity

Neurosynth connectivity image:

PAG connections based on DTI from Linnman et al.(2012)

Subregions of PAG

Animal(Rats) literatures (Resstel et al., 2008; Zhao et al., 2009)

Schematic illustration from Linnman et al.(2012)

PAG ROI

pag_roi.mat.zip

dlPAG/vlPAG coordinates

by utilizing a landmake(i.e., around the cerebral aqueduct) and Bandler's diagram.

dlPAG : x: 3/-2, y: -36.5, z: -12 vlPAG : x: 4/-2, y: -32, z: -14

Searches

Searches so far:

word [search_in] and/or/not_operators word [all] e.g., RVM [all] and Fields [author]

Most important references

Great review paper: Linnman, Moulton, Barmettler, Becerra, & Borsook (2012) Neuroimaging of the periaqueductal gray: State of the field, Neuroimage, 60, 505-522 Buhle et al.(in press) Common representation of pain and negative emotion in the midbrain periaqueductal gray, SCAN

Structure

Inputs

Name, and code Strength (L, M, H), Confidence (L, M, H), Transmitter(s)

Outputs

Name, and code Strength (L, M, H), Confidence (L, M, H), Transmitter(s)

Functions

Summary list

Function Area 1 [Name]

Effects of stimulation

  • List with references.
  • Unordered List Item

Effects of lesions/inactivation

  • List with references.
  • Unordered List Item

Effects of microinjection

  • List with references.
  • Unordered List Item

Optogenetics

  • List with references.
  • Unordered List Item

Other

Function Area 2 [Name]

Effects of stimulation

  • List with references.
  • Unordered List Item

Effects of lesions/inactivation

  • List with references.
  • Unordered List Item

Effects of microinjection

  • List with references.
  • Unordered List Item

Optogenetics

  • List with references.
  • Unordered List Item

Other

Studies activating

Coordinates

Coordinates (x, y, z):

From Linnman et al.(2012)

“225 coordinates labeled as the PAG in the manuscripts were identified: 100 were on the left, 100 on the right and 25 at the midline. The average (± SD) MNI coordinates reported as the PAG were x = −4 (left) or 4 (right) (±3 mm), y=−29 (±5), z=−12 (±7). The reported coordinates ranged 34 mm in the left-right (x) direction, 35 mm in the anterior–posterior (y) direction, and 46 mm in the dorsal-caudal (z) direction. The peak activation likelihood estimate fell at MNI x = 1, y = − 29, z = − 12.” (p.508)

Specific study coordinates

Study Description x y z
Linnman et al. 2012 Peak activation likelihood estimate 1 -29 -12
Buhle et al. 2012 Overlap of Pain and Negative Image Viewing -6 -30 -15
Napadow et al. 2008 Neural correlate of HRV -2 -27 -3

List of Studies

Specific, key studies

Study list: Coordinate based

Neurosynth results for coordinate(s)

<list studies here from Neurosynth database>

Last modified: 2017/09/27 22:53